Medicinal & Natural Products Chemistry Research Center
Adress:Shiraz University of Medical Science
P.O.Box: 71345-3388, Shiraz. Iran
Web site: http://pearl.sums.ac.ir/~mncrc
Tel & fax: 0711-2332225
Tel: 0711-2303872
E mail: mncrc@sums.ac.ir
Objective:- Synthesis of new biological active molecule and evaluation of their biological activities
- Extraction of the essential oils of local medicinal plants
- Evaluation of biological activity of plant extracts
- Phytochemical study of natural products
- Quantitative structure activity relationship(QSAR)
- Computational chemistry and molecular modeling
- Drug analysis, individually and simultaneously, by means of chemometrics or chromatographic methods
- Stability indication study of pharmaceuticalsCapability:
Human resource: expert staff on organic chemistry, medicinal chemistry computational chemistry, phytochemistry, pharmaceutical, analysis, biotechnology
Instrumental resource: HPLC, UV/Visible, IR, GC, pr-p-HPLC, counter current cheromatography, LC-MS.
Laboratory resource: synthesis computational, phytochemistry, instrumental analysis, plant biotechnology.
Table 5-6 :Academic staff:
a) full members
|
Name |
Grade |
Research area |
|
R. Miri |
Professor
Medicinal Chemist |
1-Synthesis of new 1-biological active molecule and evaluation of their biological activities.
2-Extraction and identification of components of the essential oils of local medicinal plants.
3-Evaluation of biological activity of plant extracts. |
|
K. Javidnia |
Associate Professor Medicinal Chemist |
Phytochemical & chemical Analysis |
|
B. Hemmateenijad |
Assist Professor Analytical Chemist |
Chemometrics, Structure-Activity Relationships, Pharmaceutical Analysis.
Solution Chemistry, Drug Design, Drug-Receptor Interaction. |
|
G.A. Deghani |
Professor Physiologist |
Cardiovascular physiology Vanadium and diabetes mellitus |
|
M.R. Panjehshahin |
Professor Pharmacologist |
-Studying the pharmacologic effects of active substances in herbs such as: Harmalin, lichoris, myrtle
- Pharmacologic research on animal models of acute renal failure
- Experiments on determining fatal dose of substances |
|
M.H. Tabaei |
Assoc Professor Organic Chemist |
Synthesis |
|
Z.Amirghofran |
Professor immunologist |
Cellular Immunology,Immunopharmacology |
b) Joint members:
|
Dr.Mojtaba
Shamsipur |
Professor
Analytical Chemist |
|
|
Abbas Shafee |
Professor
Medicinal Chemist |
-Heterocyclic Chemistry, Organic Reaction Mechanism, Steroids, Natural
-Products,Organic Synthesis, and Mechanism of Action of Drugs |
c) Researcher staff:
|
Dr. Mhamad Soltani |
PharMD |
Natural products chemistry & medicinal plant research |
|
Dr. Najme Edraki |
PharMD |
Synyhesis & QSAR |
|
Hanie Khalili |
Analytical Chemistry(MS) |
Chemical Analysis |
|
Maryam Elyasi |
Physical Chemistry(MS) |
QSAR & molecular modeling |
|
Maryam Gholami |
Zooalogy Biology |
Biotechnological Lab |
|
Yalda Fuladi |
Chemistry |
Chemistry Lab |
|
Azam Bagheri |
General Biology |
Pharmacology Lab |
|
Pegah Moosavi |
General Biology |
Animal
cell Culture |
Current Research Projects
1. Computational studies on antiviral elements derived from natural products.
2. Study on composition of essential oils of some plants grown in Iran.
3. Quantitative structure partition relation of terpenoids in the essential oils.
4. Preparative investigation of an anti-helicobacter pylori herbal supplement from active constituents, extracts or fractions of selected indigenous plants of Fars province.
5. Synthesis and cytotoxic activity of some pyridinyl derivatives of dihydropyridine
6. Diagnosis of HIV infection using Near-inferared (NIR) spectroscopy.
7. Determination of the preventive and therapeutic effects of curcumin in reducing the size of infarction in brain ischemia in rat.
8. The effect of quercetin and Vit E in cyclosporine A-induced hepatotoxicity and oxidative stress in rats.
9. Evaluation of antibacterial activity of date ( phoenix dactyl lifera ) on S.mutans, S. aureus, P. aeruginosa and determination of MIC & MBC
10. Synthesis and cytotoxic activity of some new Nitroimidazolyl dihydropyridine analogues
11. The role of nitric oxide and reactive oxygen species on pulmonary vascular beds during acute alveolar hypoxia, hypercapnia and hypoxic-hypercapnia in the isolated-perfused rabbit lung.
|
